Table 1 Encouraging results of MSCs application in animal kidney transplantation models
Year | Animal | MSCs source | Timing of infusion | Outcomes | References |
|---|---|---|---|---|---|
2010 | Mice | BM-MSCs | Day 1 | ↑IDO, ↑kyneurenine, ↓DCs and T cells, ↑Tregs, ↓AR, ↑graft renal function and survival | Ge et al. [26] |
2013 | Rats | BM-MSCs | Day 0 | ↓T and B cells, ↓AR, ↑graft renal function | Koch et al. [27] |
2017 | Mice | BM-MSCs-MVs | Day 1 | ↑miR-146a, ↓DCs, ↑graft renal function and survival | Wu et al. [28] |
2017 | Rats | BM-MSCs | Two injections (day − 7, 0 or day − 4, 0) | ↓T, B, and NK cells, ↑Tregs, ↓graft inflammation, ↑graft renal function and survival | Merino et al. [29] |
2017 | Rats | BM-MSCs | Three injections (day 0, 3, 7) | ↓AR, ↓pathological score, ↓TGF-β1 | Yu et al. [30] |
2007 | Rats | BM-MSCs | Four injections (day − 7, 0, 7, 14) | ↓AR, ↑graft renal function and survival | Zhang et al. [31] |
2012 | Mice | BM-MSCs | Day − 7 or day − 1 or day − 7, − 1 | ↑Tregs, ↓AR, ↑graft renal function and survival | Casiraghi et al. [32] |
2010 | Rats | BM-MSCs | Day 0 | ↓AR, ↓pathological score, ↑graft renal function | Zonta et al. [33] |
2012 | Rats | BM-MSCs | Day 77 | ↑IDO, ↓IF/TA, ↓graft inflammation, ↑graft renal function | Franquesa et al. [34] |
2014 | Porcine | AF-MSCs | Day 6 | ↑Graft renal function, ↓fibrosis | Baulier et al. [35] |
2011 | Rats | BM-MSCs | Three injections (day − 7, 0, 1) | ↓Graft inflammation, | Hara et al. [36] |