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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Adipose mesenchymal stem cell transplantation alleviates spinal cord injury-induced neuroinflammation partly by suppressing the Jagged1/Notch pathway

Fig. 4

Neurons were the main cells that mediated Notch signaling after SCI. Double immunofluorescence staining of NICD and Jagged1 in the spinal cords of the SCI group mice 7 days after SCI. The nuclei were stained with DAPI (blue). NICD was mainly localized in NeuN-positive neurons, no NICD signal was observed in astrocytes, and only a small portion of IBA1-positive microglia/macrophages were positive for NICD. Jagged1 was obviously expressed by NeuN-positive neurons and GFAP-positive astrocytes, and the Jagged1 signal in IBA1-positive microglia/macrophages was weak. Scale bars: 50 μm

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Stem Cell Research & Therapy

ISSN: 1757-6512