Skip to main content
Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Adipose mesenchymal stem cell transplantation alleviates spinal cord injury-induced neuroinflammation partly by suppressing the Jagged1/Notch pathway

Fig. 7

Jagged1 knockdown inhibited JAK/STAT3 signaling in astrocytes. a Representative western blot images showing the protein levels of JAK/STAT3 pathway-related molecules at 3 days after Jagged1 siRNA injection. The quantification of p-STAT3 (b), STAT3 (c), and JAK (d) (n = 4; the data are expressed as the mean ± SEM; *P < 0.05 versus the sham group; #P < 0.05 versus the SCI+scramble siRNA group). e Representative images of the lesion area in the spinal cord sections double-stained for pSTAT3 and GFAP. The cell nuclei were counterstained with DAPI. f The quantification of the STAT3-positive area. Jagged1 siRNA injection significantly reduced the STAT3-positive area at 3 days after SCI. g The quantification of the GFAP-positive area. There was no significant difference in the GFAP-positive area among the three groups at 3 days after SCI

Back to article page