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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Induced pluripotent stem cell-derived lung alveolar epithelial type II cells reduce damage in bleomycin-induced lung fibrosis

Fig. 5

a, b Changes in the mRNA expression of markers for fibroblast activation (TGF-β and α-SMA) were evaluated by Selfie-qPCR. Data are means ± SEM of 6 animals per group (*p < 0.05 vs control groups, #p < 0.05 vs BLM). c Immunohistological staining with anti-α-SMA (green) shows the presence of α-SMA-positive fibroblast in BLM animals. iPSC-AEC2 cell transplantation reduces the number of α-SMA-positive cells. (magnification × 400). d Graph of integrated optical density (area × density) of each band using Image-Pro plus software for α-SMA analyzed by immunoblot and normalized to β-actin (n = 2 for control, control + iPSC-AEC2, and BLM; n = 3 for iPSC-AEC2). Data are means + SEM (n = 2 for control, control + iPSC-AEC2, and BLM; n = 3 for iPSC-AEC2)

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Stem Cell Research & Therapy

ISSN: 1757-6512