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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Mesenchymal stem cell-derived exosomes improve motor function and attenuate neuropathology in a mouse model of Machado-Joseph disease

Fig. 4

Injection of MSC-derived exosomes significantly attenuated hypomyelination in YACMJD84.2 mice. a Immunofluorescence images of MBP protein in the cerebellar lobules (n = 4). The pictures were captured with a two-photon confocal laser scanning microscope at × 25 magnification. The scale bar was 100 μm. b Quantitative analysis of MBP signal intensity (n = 4). One-way ANOVA analysis; *p ≤ 0.05, **p ≤ 0.01. c Western blot analysis of MBP expression among YACMJD84.2 mice with exosomal treatment (Exosome-Tg, n = 4), YACMJD84.2 mice without exosomal treatment (Control-Tg, n = 4), and wild-type littermates (Control-Wt, n = 4). d Quantitative analysis of relative MBP expression. One-way ANOVA analysis; *p ≤ 0.05, **p ≤ 0.01

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