Table 1 General characteristics of preclinical studies investigating the efficacy of mesenchymal stem cells in models of sepsis

Gonzalez-Rey et al. (2009)A Spain [10]

Mouse BALB/c, NR

18

10

CLP

Adipose, Xenogenic or Allogeneic

1.0×10⁶

4 hours

IP

DMEM

Gonzalez-Rey et al. (2009)B Spain

Mouse BALB/c, NR

20

10

LPS (i.p.)

Adipose, Xenogenic or Allogeneic

1.0 × 10⁶ or 3.0 × 10⁵

0.5 hours

IP

DMEM

Nemeth et al. (2009) United States [11]

Mouse C57BL/6, M

90

45

CLP

Bone marrow, Allogeneic

1.0×10⁶

0 or 1 hour

IV

PBS

Bi et al. (2010) China [12]

Mouse C57BL/6, NR

10

10

CLP

Bone marrow, Xenogenic

1.0×10⁶

1 1 hours

IV

PBS

Mei et al. (2010)A Canada [13]

Mouse C57BL/6J, F

29

29

CLP

Bone marrow, Syngeneic

2.5×10⁵

6 hours

IV

NS

Mei et al. (2010)B Canada

Mouse C57BL/6J, F

15

20

CLP

Bone marrow, Syngeneic

2.5×10⁵

6 hours

IV

NS

Liang et al. (2011) China [14]

Rat Wistar, F

15

15

LPS (i.v.)

Bone marrow, Syngeneic

1.0×10⁶

2 hours

IV

NS

Chang et al. (2012) China [15]

Rat SPD, M

16

16

CLP

Adipose, Autologous

3× 1.2×10⁶

0.5, 6 then 18

IP

NS

Krasnodembskaya et al. (2012) USA [16]

Mouse C57BL/6J, M

34

69

P. aeruginosa (i.p.)

Bone marrow, Xenogenic

1.0×10⁶

1 hour

IV

PBS

Li et al. (2012) China [17]

Rat SPD, M

20

40

LPS (i.p.)

Umbilical cord, Xenogenic

5.0×10⁵

1 hour

IV

NS

Hall et al. (2013) USA [18]

Mouse BALB/c, M

26

35

CLP

Bone marrow, Syngeneic

1× 5.0 ×10⁵ + 2 ×2.5× 10⁵

2 then 24 then 48 hours

IV

PBS

Zhao et al. (2013) China [19]

Rat SPD, F

24

27

LPS (i.v.)

Bone marrow, Syngeneic

2.5×10⁶

2 hours

IV

NS

Chao et al. (2014) Taiwan [20]

Rat Wistar, M

20

10

CLP

Bone Marrow or Umbilical Cord, Xenogenic

5.0×10⁶

4 hours

IV

PBS

Kim et al. (2014) Canada [21]

Mouse C57BL/6, M

73

66

SEB+ (i.p)

Bone marrow, Syngeneic

2.5×10⁵

3 hours

IV

PBS

Luo et al. (2014) China [22]

Mouse C57Bl/6, M

20

20

CLP

Bone marrow, Syngeneic

1.0×10⁶

3 hours

IV

NS

Pedrazza et al. (2014) Brazil [23]

Mouse C57BL/6, M

15

15

E. coli (i.p.)

Adipose, Syngeneic

1.0×10⁶

0

IV

PBS

Sepulveda et al. (2014) Spain [24]

Mouse BALB/c, M

30

10

LPS (i.p.)

Bone Marrow, Xenogenic

1.0×10⁶

0.5 hour

IP

PBS

Zhao et al. (2014) China [25]

Mouse C57BL/6, M

12

12

CLP

Umbilical cord, Xenogenic

1.0×10⁶

1 hour

IV

NS

Zhou et al. (2014) China [26]

Mouse NOD SCID, M

7

7

LPS+ (i.p.)

Umbilical Cord, Xenogenic

2.0×10⁶

6 hours

IV

No treatment

Yang et al. (2015) China [28]

Mouse NOD SCID, M

10

10

LPS+ (i.p.)

Umbilical cord, Xenogenic

5.0×10⁵

0

IV

DMEM

Francisca et al.(2015) Chile [27]

Mouse C57BL6/j, NR

21

16

CLP

menstrual fluid, Xenogenic

7.5 × 10⁵

3 hours

IV/IP

NS

Hao Ou et al.(2015)A China [29]

Mouse SPF BALB/c, NR

7

14

LPS

Adipose, Allogeneic

1.0 × 10⁷

5 mins

IV

NS

Hao Ou et al.(2015)B China

Mouse SPF BALB/c, NR

9

14

LPS

Bone marrow, Allogeneic

1.0 × 10⁷

5 mins

IV

NS

Pei-Hsun Sung et al.(2017) Taiwan, China [30]

Rats SPD, M

16

16

CLP

Adipose, Autologous

1.2×10⁶

3 hours

IV

NS

Xujing Liang et al.(2019) China [33]

Rats SPD, M

10

10

CLP

Umbilical cord, Xenogenic

2.5×10⁶

0

IV

PBS

Xian-Fei Ding et al.(2019) China [31]

Rats SPD, M

30

30

CLP

Adipose, Allogeneic

1.0×10⁶

1 hour

IP

NS

Mirjana Jerkic et al.(2019)A Canada [32]

Rats SPD, M

12

15

E. coli

Umbilical cord, Xenogenic

1.0× 10⁷

1 hour

IV

PBS

Mirjana Jerkic et al.(2019)B Canada

Rats SPD, M

11

15

E. coli

IL-10 UC-MSCs, Xenogenic

1.0 × 10⁷

1 hour

IV

PBS

Huoyan Liang et al.(2019) China [41]

Rats SPD, M

20

20

CLP

Adipose, Allogeneic

1.0×10⁶

1 hour

IP

NS