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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: RETRACTED ARTICLE: Mesenchymal stem cell-derived exosomes exert ameliorative effects in type 2 diabetes by improving hepatic glucose and lipid metabolism via enhancing autophagy

Fig. 5

HucMDEs improve the glucose and lipid metabolism by promoting autophagy. a L-O2 cells were treated with PA, PA + HucMDEs, PA + 3-MA, or PA+ HucMDEs + 3-MA. Protein levels of MAP 1LC3B were examined by Western blotting. Glycolysis-related proteins (GCK, PFK, PK) (b), glycogen synthesis-related proteins (p-GSK3β, GSK3β) (c), and gluconeogenesis-related proteins (G-6-P, PEPCK) (d) in L-O2 cells of the indicated groups were detected by Western blotting. e PAS staining of L-O2 cells in the indicated groups. f SREBP-1c and PPARα in L-O2 cells of the indicated groups were detected by Western blotting. All results are expressed as the mean ± SD (*P < 0:05; **P < 0:01; ***P < 0.001)

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Stem Cell Research & Therapy

ISSN: 1757-6512