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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: RETRACTED ARTICLE: Heme oxygenase-1-modified bone marrow mesenchymal stem cells combined with normothermic machine perfusion to protect donation after circulatory death liver grafts

Fig. 5

Liver function, histopathology of liver grafts, and the Suzuki score at different time points. A Liver function after transplantation. On POD 1, ALT levels between the SCS (882.01 ± 139.46 U/L) and NMP groups (359.42 ± 85.13 U/L) were significantly different (P < 0.05), but the difference was not significant between the NMP, BP, and HBP groups (P > 0.05). However, on POD 1 and 7, ALT levels in the HBP (96.78 ± 35.76 U/L) and BP groups (189.46 ± 47.21 U/L) were lower than those in the SCS (395.20 ± 112.57 U/L) and NMP groups (217.46 ± 36.42 U/L), and levels in the HBP group were lower than those in the BP group. The difference was significant (P < 0.05), and the AST, ALP, GGT, and TBil trends were similar to ALT. B Pathology of liver grafts at different time points (H&E staining, × 100). On POD 1, hepatic sinusoids were enlarged and vacuolar degeneration was detected in the SCS group. A small amount of vacuolar degeneration was also observed in the NMP, BP, and HBP groups. On POD 7, partial lobular destruction was observed in the SCS group, along with liver sinus congestion and infiltration of a large number of inflammatory cells; however, these effects were improved on POD 14. The liver tissue structure was more intact in the BP group than in the SCS and NMP groups. The hepatic lobular structure of the HBP group was relatively intact, with infiltration of a small number of inflammatory cells, and its tissue structure was improved compared to that of BP group. C The Suzuki score at different time points (aP < 0.05 vs. SCS group; bP < 0.05 vs. NMP group; cP < 0.05 vs. HBP group)

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