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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Hypoxia-challenged MSC-derived exosomes deliver miR-210 to attenuate post-infarction cardiac apoptosis

Fig. 5

Exosomes derived from MSCs with miR-210 overexpression inhibit apoptosis after myocardial infarction. a Western blot analysis of protein levels of apoptosis-associated genes BAD, BAX, BCL-2, and Cleaved-CASPASE-3 from cardiac tissue samples from mice in the indicated treatment groups. Each experiment was repeated 3 times. b Cell death in tissue samples was characterized by TUNEL assay. **p < 0.01, ***p < 0.001, ****p < 0.0001 for MI + exomiR210, MI + exoanti-miR210, MI + exoVehicle vs. MI. #p < 0.05 for MI + exomiR210, MI + exoanti-miR210 vs. MI + exoVehicle

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Stem Cell Research & Therapy

ISSN: 1757-6512