Fig. 8

Comparison of the uptake of exosomal miR-210 with the regulatory activity of endogenous miR-210. The protein levels of AIFM3, p-AKT/AKT, p-PI3K/PI3K, p-p53/p53, BAD, BAX, BCL-2, and Cleaved-CASPASE-3 were evaluated by Western blotting in cardiomyocytes treated with overexpressed miR-210. Quantifications are shown in the lower panel. N = 3 independent experiments. **p < 0.01, ***p < 0.001, ****p < 0.0001 for miR-210 agomir and miR-210 antagomir vs. con. ^##p < 0.01, ^###p < 0.001 for miR-210 agomir NC vs. miR-210 agomir. ⁺p < 0.05, ⁺⁺⁺p < 0.001, ⁺⁺⁺⁺p < 0.0001 for miR-210 antagomir NC vs. miR-210 antagomir