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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Plasma membrane vesicles of human umbilical cord mesenchymal stem cells ameliorate acetaminophen-induced damage in HepG2 cells: a novel stem cell therapy

Fig. 2

Bioinformatic analysis of the transcript profile of hUCMSCs and PMVs. Total RNAs were harvested from two preparations of hUCMSCs and PMVs and sent to Hengchuangjiyin Technology (China) for bioinformatic analysis (a, b) Diagrams (left) show the number of differentially expressed genes (DEGs) from preparations 1 and 2 of hUCMSCs vs. PMVs. The overlap of 2 circles represents common genes in both PMVs and hUCMSCs. Downregulated and upregulated DEGs were indicated with an arrow. Bar graphs (right) show genes with at least a 4-fold difference in the transcript levels for hUCMSCs vs. PMVs. The heat map of Euclidean distance (c) and hierarchical clustering profile (d) show the similarity between the transcripts of hUCMSCs and PMVs. The vertical distance reflects the similarity between samples (c). e, f GO term analysis of DEGs with at least 4-fold difference in the transcript levels between hUCMSCs and PMVs of preparations 1 and 2

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