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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Intra-carotid arterial transfusion of circulatory-derived autologous endothelial progenitor cells in rodent after ischemic stroke—evaluating the impact of therapeutic time points on prognostic outcomes

Fig. 4

Expressions of endothelial cell biomarkers in brain infarct zone at day 60 after acute IS. ag Illustrating immunofluorescent (IF) microscopic finding (× 400) for identification of the expression of CD31+ cells (green color). Red color in c to g indicated the dye-stained implanted ECPs. h Analytical result of number of CD31+ cells, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 vs. IS. io Illustrating IF microscopic finding (× 400) for identification of the expression of von Willebrand factor (vWF) + cells (green color). Red color in k to o indicates the dye-stained implanted ECPs. p Analytical result of number of vWF+ cells, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 vs. IS. Scale bars in lower right corner represent 20 μm. All statistical analyses were performed by one-way ANOVA, followed by Bonferroni multiple-comparison post hoc test (n = 6 for each group). LCCA = left common carotid artery. SC = sham-operated control; IS = ischemic stroke (IS); EPC3h = EPC administration from LCCA at 3 h after acute IS; EPC3d = EPC administration from LCCA at day 3 after acute IS; EPC7d = EPC administration from LCCA at day 7 after acute IS; EPC14d = EPC administration from LCCA at day 14 after acute IS; EPC28d = EPC administration from LCCA at day 28 after acute IS

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