Fig. 7
Protein expressions of inflammatory and oxidative stress biomarkers in brain infarct zone at day 60 after acute IS. a Protein expression of tumor necrosis factor (TNF-α), *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 vs. IS. b Protein expression of phosphorylated nuclear factor (p-NF)-κB, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 vs. IS. c Protein expression of matrix metalloproteinase (MMP)-9, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 vs. IS. d Protein expression of NOX-1, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 vs. IS. e Protein expression of NOX-2, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 vs. IS. f Protein expression of p22phox, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 vs. IS. g The oxidized protein expression, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 vs. IS (Note: the right and left lanes shown on the upper panel represent protein molecular weight marker and control oxidized molecular protein standard, respectively). M.W. = molecular weight; DNP = 1–3 dinitrophenylhydrazone. All statistical analyses were performed by one-way ANOVA, followed by Bonferroni multiple-comparison post hoc test (n = 6 for each group). LCCA = left common carotid artery. SC = sham-operated control; IS = ischemic stroke (IS); EPC3h = EPC administration from LCCA at 3 h after acute IS; EPC3d = EPC administration from LCCA at day 3 after acute IS; EPC7d = EPC administration from LCCA at day 7 after acute IS; EPC14d = EPC administration from LCCA at day 14 after acute IS; EPC28d = EPC administration from LCCA at day 28 after acute IS