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Fig. 8 | Stem Cell Research & Therapy

Fig. 8

From: Intra-carotid arterial transfusion of circulatory-derived autologous endothelial progenitor cells in rodent after ischemic stroke—evaluating the impact of therapeutic time points on prognostic outcomes

Fig. 8

Protein expressions of autophagic and apoptotic biomarkers in brain infarct zone at day 60 after acute IS. a Protein expression of beclin-1, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 vs. IS. b Protein expression of Atg-5, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 vs. IS. c Protein expression of ratio of LC3B-II/LC3B-I, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 vs. IS. d Protein expression of mitochondrial (mito)-Bax, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 vs. IS. e Protein expression of cleaved caspase 3 (c-Csp3), *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 vs. IS. f Protein expression of cleaved Poly (ADP-ribose) polymerase (c-PARP), *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 vs. IS. All statistical analyses were performed by one-way ANOVA, followed by Bonferroni multiple-comparison post hoc test (n = 6 for each group). LCCA = left common carotid artery. SC = sham-operated control; IS = ischemic stroke (IS); EPC3h = EPC administration from LCCA at 3 h after acute IS; EPC3d = EPC administration from LCCA at day 3 after acute IS; EPC7d = EPC administration from LCCA at day 7 after acute IS; EPC14d = EPC administration from LCCA at day 14 after acute IS; EPC28d = EPC administration from LCCA at day 28 after acute IS

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