Skip to main content
Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: TNFα/TNFR2 signaling pathway: an active immune checkpoint for mesenchymal stem cell immunoregulatory function

Fig. 7

The expression of TNFR2 on MSCs is leading to the induction of T regs with a more activated phenotype. The activation status of the T regs that were induced after the co-culture of CD4+ conventional T cells with MSCs WT or TNFR2 KO was evaluated. Cells were gated on CD4+Foxp3+T cells. For each marker, the strategy of gating is indicated on the left and under the figure. Each dot represents a measured value (n = 4) collected from 2 different experiments. For each group of values, horizontal lines represent the mean value and standard error of the mean. Unpaired Student t test analysis was performed to generate P values. ns, non-significant; **P < .01, ***P < .001. iTregs, induced T reg cells

Back to article page