Fig. 5
FNDC5 promoted the retention effect of engrafted BM-MSCs. a Longitudinal BLI spatiotemporally tracked MSCsFluc+GFP+ survival in MI with preconditioned mesenchymal stem cells (MPCMSCs) (top row, n = 10) and FNDC5-MSCs preconditioned MSCs (MFPCMSCs) (second row, n = 10). Color scale bar values are in photons/s/cm2/sr. b Representative quantitative analysis of firefly luciferase (Fluc) optical signals on fixed regions of interest (ROI). c Representative confocal laser microscopic images of BM-MSCs (GFP, green fluorescence), cardiomyocytes (cTn I, red florescence), and DAPI (blue fluorescence) at 2 weeks after engraftment (scale bar:50 μm). d Quantitative analysis of the ratio of GFP/DAPI. Data are expressed as means ± SEM; n = 5; *p < 0.05