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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Pulp stem cells with hepatocyte growth factor overexpression exhibit dual effects in rheumatoid arthritis

Fig. 1

Clinical manifestation of CIA in mice after different treatments. a The flow diagram shows the study design of immunization and the following analysis. b The photographs represent the typical inflamed joints. Severe arthritis presents as joint rashes, swelling, and stiffness. The experiments have repeated once. c Clinical evaluation is presented in the statistical charts. The line graph shows the clinical scores of inflamed mice. The clinical score of each mouse was the sum of the arthritic limbs. For each limb, the quantification was conducted according to the criteria using a scale of 0–4, with 4 being the most severe inflammation. The mean severity score is the average score of each arthritic mouse. Incarnadine line with dots represents normal control group, red line with squares represents the PBS group, blue line with triangles represents the DPSCs-Null treatment group, and green line with triangles represents the DPSCs-HGF treatment group (each group contains 10 mice. # represents p < 0.05, ## represent p < 0.01 (PBS group vs. DPSCs-Null group); & represents p < 0.05, && represent p < 0.01 (PBS group vs. DPSCs-HGF group); ** represent p < 0.01 (DPSCs-Null group vs. DPSCs-HGF group)

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