Fig. 3
From: Generation of myogenic progenitor cell-derived smooth muscle cells for sphincter regeneration
Change in the gene expression of MPC and MSC during SMC differentiation. Changes in the gene expression were assessed by microarray analysis of RNA isolated from MSC, MPC, MSC-SMC, and MPC-SMC. Cells derived from two individual human muscle biopsies were cultivated in growth (MSC and MPC) or smooth muscle differentiation medium (MSC-SMC and MPC-SMC) for 6 days, respectively. a Hierarchical clustering (Euclidean distance) of Log2 fold changes of smooth muscle-associated genes in MSC vs MSC-SMC (MSC) and MPC vs MPC-SMC (MPC). The cluster of genes similarly b upregulated or c downregulated in both MSC and MPC upon SMC differentiation obtained by k-means clustering. *Genes which in both cell types were either log2 FC ≥ 1 or log2 FC ≤ − 1 up- or downregulated. d Percent of tested genes calculated to be upregulated or downregulated during MSC to MSC-SMC or MPC to MPC-SMC differentiation. Statistical comparison was performed by chi-squared test considering a p value below 0.05 as significant