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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Mesenchymal stem cells transfected with sFgl2 inhibit the acute rejection of heart transplantation in mice by regulating macrophage activation

Fig. 2

The effects and related mechanism of sFgl2-MSCs on the polarization of macrophages. a Flow cytometry analysis of CD16/32 and CD206 expressions of macrophages cultured alone, cultured with CsA, or co-cultured with WT-MSCs, MSCs-NC, and sFgl2-MSCs with or without the stimulation of LPS+IFN-γ respectively for 72 h. bd The mRNA expression of STAT1, IκB, and p65 in the macrophages cultured alone, cultured with CsA, or co-cultured with WT-MSCs, MSCs-NC, and sFgl2-MSCs with the stimulation of LPS+IFN-γ respectively for 72 h. e The phosphorylation and total protein expressions of STAT1, IκB, and p65 in the macrophages cultured alone, cultured with CsA, or co-cultured with WT-MSCs, MSCs-NC, and sFgl2-MSCs with the stimulation of LPS+IFN-γ for 72 h. The data were reported as mean ± SD, n = 3. *Significant difference, P < 0.05; **significant difference, P < 0.01; ***significant difference, P < 0.001

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