Fig. 4From: Melatonin-stimulated MSC-derived exosomes improve diabetic wound healing through regulating macrophage M1 and M2 polarization by targeting the PTEN/AKT pathwayMT-Exo expedited diabetic wound healing in vivo. a, b Optical images and related quantification of the wound closure rate of full-thickness dermal defects in the Control group, Exo group and MT-Exo group at day 0, 7 and 14 after the skin operation (n = 3, *p < 0.05, Scale bar = 10 mm). c, d H&E staining images and related quantification of total neoepithelium length in the Control group, Exo group and MT-Exo group at days 7 and 14 (n = 3, *p < 0.05). e The relative gene expression of the angiogenesis-related gene α-SMA and collagen synthesis-related genes Collagen I and III in the Control, Exo, and MT-Exo groups (n = 3, *p < 0.05)Back to article page