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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Melatonin-stimulated MSC-derived exosomes improve diabetic wound healing through regulating macrophage M1 and M2 polarization by targeting the PTEN/AKT pathway

Fig. 4

MT-Exo expedited diabetic wound healing in vivo. a, b Optical images and related quantification of the wound closure rate of full-thickness dermal defects in the Control group, Exo group and MT-Exo group at day 0, 7 and 14 after the skin operation (n = 3, *p < 0.05, Scale bar = 10 mm). c, d H&E staining images and related quantification of total neoepithelium length in the Control group, Exo group and MT-Exo group at days 7 and 14 (n = 3, *p < 0.05). e The relative gene expression of the angiogenesis-related gene α-SMA and collagen synthesis-related genes Collagen I and III in the Control, Exo, and MT-Exo groups (n = 3, *p < 0.05)

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