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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Melatonin-stimulated MSC-derived exosomes improve diabetic wound healing through regulating macrophage M1 and M2 polarization by targeting the PTEN/AKT pathway

Fig. 5

MT-Exo improves angiogenesis and collagen synthesis in diabetic rats in vivo. a The assessment of the neovessels in the Control group, Exo group and MT-Exo group by α-SMA IHC at day 7 and 14 (red arrows display neovessels, Scale bar = 100 μm). b IF evaluation for CD31/α-SMA in the Control group, Exo group and MT-Exo group at days 7 and 14 (Scale bar = 100 μm). c The evaluation of neovasculars via the Microfil imaging method. d Quantification of the number of neovessels per field at day 7 and 14 by IHC (n = 3, *p < 0.05). e Quantification of the number of neovessels per field at day 7 and 14 by IF. f Quantification of the number of neovasculars per field at day 7 and 14 by Microfil. g Masson’s trichrome staining at day 7 and 14 post-operationally (Scale bar = 200 μm for 100× and 50 μm for 400×)

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