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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Vagal-α7nAChR signaling promotes lung stem cells regeneration via fibroblast growth factor 10 during lung injury repair

Fig. 3

α7nAChR activation accelerates LSCs expansion at the late phase of LPS-induced lung injury. a A scheme shows the timing of the interventional measures. LPS (2.5 mg/kg) with PBS or LPS (2.5 mg/kg) with GTS-21 1 (α7nAChR agonist; 4 mg/kg) was intratracheally delivered to mice and was followed up with for 1, 3, 7, or 14 days. bd Changes are shown for LSCs (b) and Ki67+ LSCs (c) as well as the lung injury score (d) in PBS- or GTS-21 (4 mg/kg)-treated mice after LPS (2.5 mg/kg) challenge at 1, 3, 7, and 14 days. e Representative photographs of lung pathologic changes stained by hematoxylin and eosin in PBS- or GTS-21-treated mice after LPS (2.5 mg/kg) challenge at 1, 3, 7, and 14 days; scale bar, 100 μm. N = 3–4 in each group. Data are presented as the mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.00, assessed by one-way ANOVA

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