Fig. 5

Vagal-α7nAChR signaling upregulates FGF10 expression and enhances LSCs proliferation and transdifferentiation to AEC2. a The lung protein expression levels of fibroblast growth factors 10 (FGF10) were measured by immunohistochemistry in the Sham+PBS, Sham+LPS, Vx+LPS, or Vx+LPS+GTS-21 groups. b The statistical results of a. c The relative FGF10 mRNA expression in the lungs of the Sham+PBS, Sham+LPS, Vx+LPS, and Vx+LPS+GTS-21 groups. d The SP-C⁺ cells (alveolar epithelial type II cells, AEC2) mass measured by immunohistochemistry in the Sham+PBS, Sham+LPS, Vx+LPS, and Vx+LPS+GTS-21 groups. e The statistical results of d. f The relative SP-C mRNA expression of lung in Sham+PBS, Sham+LPS, Vx+LPS, or Vx+LPS+GTS-21 groups. N = 3–6 in each group. Data are presented as the mean ± SD. *P < 0.05, **P < 0.01, and ***P < 0.00, as assessed by one-way ANOVA