Fig. 6

FGF10 reverses α7nAChR knockout-induced loss of Ki67⁺ LSCs. a Schematic model of FGF10 administration in LPS-challenged mice. Wild-type (α7nAChR^+/+) or α7nAChR knockout (α7nAChR^−/−) mice were intratracheally treated with FGF10 (5 mg/kg) 3 days before LPS (2.5 mg/kg) challenge and then were killed 7 days after LPS challenge. b Representative photographs of lung pathologic changes stained by hematoxylin and eosin; scale bar, 200 μm. c Changes in the lung injury score. d The percentage changes of Ki67⁺ cells gated out of total live lung cells. e The number of Ki67⁺ LSCs. f The percentage changes of LSCs gated on total lung living cells. N = 4–6 in each group. Data are presented as the mean ± SD. *P < 0.05, **P < 0.01, and ***P < 0.00, as assessed by one-way ANOVA