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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: The safety and effectiveness of genetically corrected iPSCs derived from β-thalassaemia patients in nonmyeloablative β-thalassaemic mice

Fig. 2

Morphology of iPSCs and ESCs in the OP9 coculture system and CFU assays performed with CD34+ cells from different groups. a Images of the typical morphology of iPSCs and ESCs in the OP9 coculture system used to induce haematopoietic differentiation at D2 and D10; scale bar, 100 μm. b Flow cytometry analysis of human CD34+ cell proportions in the four groups (α-MEM, hESC, piPSC and ciPSC groups) after coculture with OP9 cells. c Morphology of colonies of CD34+ haematopoietic progenitors derived from iPSCs cocultured with OP9 cells; scale bar, 50 μm. HSCs induced differentiation into erythroid cells (E), macrophages (M), granulocytes (G), granulocytes/macrophages (GMs) and granulocytes/erythrocytes/monocytes/megakaryocytes (GEMMs)

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Stem Cell Research & Therapy

ISSN: 1757-6512