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Table 1 Summary of routine blood test parameters of six groups of β-thalassaemic mice before and after transplantation from week 0 to week 5 after nonmyeloablative treatment

From: The safety and effectiveness of genetically corrected iPSCs derived from β-thalassaemia patients in nonmyeloablative β-thalassaemic mice

 

Weight (g)

RBC (1012/l)

HB (g/l)

HCT (%)

0 week

 α-MEM group (n = 3)

19.30 ± 0.71

7.52 ± 0.58

92.67 ± 5.51

31.07 ± 2.37

 UCBC group (n = 3)

18.77 ± 1.68

7.89 ± 0.71

98.00 ± 8.00

32.33 ± 3.55

 hESC group (n = 3)

19.70 ± 0.90

7.69 ± 0.45

94.33 ± 5.13

31.77 ± 1.44

 niPSC group (n = 3)

19.77 ± 0.68

7.28 ± 0.45

89.00 ± 4.58

30.43 ± 1.61

 piPSC group (n = 3)

18.93 ± 1.24

7.38 ± 0.39

90.00 ± 4.36

31.13 ± 0.50

 ciPSC group (n = 3)

20.00 ± 1.39

7.46 ± 0.25

92.00 ± 1.73

31.05 ± 0.78

1 week

 α-MEM group (n = 3)

20.80 ± 0.85

2.96 ± 0.13

34.33 ± 4.16

18.17 ± 3.84

 UCBC group (n = 3)

20.60 ± 1.50

2.99 ± 0.45

37.67 ± 5.03

12.50 ± 2.36

 hESC group (n = 3)

21.10 ± 0.72

2.77 ± 0.53

33.67 ± 6.66

11.63 ± 2.91

 niPSC group (n = 3)

21.00 ± 0.36

2.95 ± 0.53

35.00 ± 5.29

7.77 ± 2.70

 piPSC group (n = 3)

20.80 ± 0.70

2.70 ± 0.26

32.50 ± 2.12

14.25 ± 1.63

 ciPSC group (n = 3)

20.93 ± 1.88

3.20 ± 0.52

39.67 ± 6.51

15.53 ± 4.45

2 weeks

 α-MEM group (n = 3)

21.55 ± 1.63

5.11 ± 0.69

65.50 ± 9.19

33.00 ± 12.02

 UCBC group (n = 3)

21.90 ± 0.85

6.04 ± 0.73

74.00 ± 11.31

33.45 ± 7.00

 hESC group (n = 3)

20.13 ± 2.53

5.47 ± 0.42

68.50 ± 3.54

22.13 ± 13.86

 niPSC group (n = 3)

19.17 ± 3.41

5.83 ± 0.40

70.00 ± 5.66

18.00 ± 20.38

 piPSC group (n = 3)

22.45 ± 0.07

5.28 ± 0.35

65.00 ± 5.66

32.65 ± 2.76

 ciPSC group (n = 3)

22.27 ± 2.16

6.03 ± 0.35

73.00 ± 5.66

25.30 ± 7.91

3 weeks

 α-MEM group (n = 3)

21.60 ± 0.99

6.08 ± 0.28

74.50 ± 3.54

33.30 ± 0.57

 UCBC group (n = 3)

22.30 ± 0.85

6.57 ± 0.09

81.00 ± 2.83

28.35 ± 0.21

 hESC group (n = 3)

20.70 ± 1.13

6.77 ± 0.62

83.50 ± 4.95

30.85 ± 3.18

 niPSC group (n = 3)

21.00 ± 1.27

6.58 ± 0.47

79.00 ± 8.49

32.45 ± 3.04

 piPSC group (n = 3)

20.90 ± 0.14

6.06 ± 0.37

73.00 ± 7.07

30.40 ± 2.55

 ciPSC group (n = 3)

21.50 ± 1.37

6.42 ± 0.42

78.67 ± 6.43

30.20 ± 1.08

4 weeks

 α-MEM group (n = 3)

21.40 ± 1.70

6.61 ± 0.46

82.50 ± 3.54

29.60 ± 0.14

 UCBC group (n = 3)

22.80 ± 1.56

7.09 ± 0.64

86.50 ± 4.95

30.40 ± 3.11

 hESC group (n = 3)

21.05 ± 0.78

6.97 ± 0.70

87.50 ± 4.95

31.30 ± 2.40

 niPSC group (n = 3)

21.20 ± 1.41

6.97 ± 1.52

85.50 ± 17.68

31.05 ± 7.00

 piPSC group (n = 3)

20.05 ± 0.21

6.92 ± 0.28

85.00 ± 5.66

30.00 ± 0.28

 ciPSC group (n = 3)

21.17 ± 1.61

6.42 ± 0.17

79.33 ± 2.31

29.30 ± 1.61

5 weeks

 α-MEM group (n = 3)

23.95 ± 1.06

6.78 ± 0.50

83.00 ± 5.66

30.10 ± 0.14

 UCBC group (n = 3)

23.10 ± 0.07

6.91 ± 0.21

84.00 ± 1.41

28.65 ± 1.20

 hESC group (n = 3)

23.45 ± 1.34

6.51 ± 0.08

78.50 ± 0.71

28.00 ± 0.71

 niPSC group (n = 3)

23.55 ± 1.34

6.91 ± 1.03

86.50 ± 14.85

30.00 ± 4.95

 piPSC group (n = 3)

22.25 ± 0.21

6.39 ± 0.22

79.00 ± 4.24

27.00 ± 0.57

 ciPSC group (n = 3)

23.87 ± 1.66

6.58 ± 0.79

81.33 ± 10.02

29.23 ± 2.41

 

MCV (fl)

MCH (pg)

MCHC (g/l)

RET%

0 week

 α-MEM group (n = 3)

41.27 ± 0.35

12.33 ± 0.21

298.67 ± 4.93

14.64 ± 2.06

 UCBC group (n = 3)

40.97 ± 1.01

12.43 ± 0.12

304.00 ± 9.17

12.99 ± 3.18

 hESC group (n = 3)

41.33 ± 0.57

12.30 ± 0.17

296.67 ± 3.21

13.16 ± 4.13

 niPSC group (n = 3)

41.77 ± 0.38

12.23 ± 0.21

292.33 ± 2.89

13.14 ± 3.37

 piPSC group (n = 3)

42.30 ± 1.65

12.23 ± 0.12

289.00 ± 10.15

14.99 ± 6.27

 ciPSC group (n = 3)

43.00 ± 1.51

12.33 ± 0.15

287.00 ± 13.00

18.13 ± 1.76

1 week

 α-MEM group (n = 3)

47.07 ± 3.75

12.67 ± 0.29

270.00 ± 20.52

8.18 ± 4.05

 UCBC group (n = 3)

41.60 ± 1.71

12.60 ± 0.50

304.00 ± 22.61

4.00 ± 0.64

 hESC group (n = 3)

41.67 ± 3.00

12.17 ± 0.29

292.33 ± 18.58

3.88 ± 2.23

 niPSC group (n = 3)

40.90 ± 3.15

12.43 ± 0.35

305.00 ± 22.61

3.85 ± 1.15

 piPSC group (n = 3)

42.95 ± 1.34

12.50 ± 0.00

292.00 ± 8.49

4.42 ± 0.18

 ciPSC group (n = 3)

47.83 ± 6.25

12.37 ± 0.06

261.67 ± 33.65

8.40 ± 5.98

2 weeks

 α-MEM group (n = 3)

50.45 ± 3.61

12.30 ± 0.71

243.50 ± 3.54

54.45 ± 4.88

 UCBC group (n = 3)

49.70 ± 2.69

12.15 ± 0.21

245.00 ± 18.38

34.25 ± 19.16

 hESC group (n = 3)

54.40 ± 1.35

12.07 ± 0.87

221.67 ± 10.21

40.75 ± 19.76

 niPSC group (n = 3)

51.37 ± 3.86

11.30 ± 1.18

221.00 ± 31.95

30.13 ± 17.03

 piPSC group (n = 3)

52.10 ± 4.95

12.50 ± 0.00

241.00 ± 22.63

56.30 ± 11.88

 ciPSC group (n = 3)

54.10 ± 3.04

12.33 ± 0.15

227.67 ± 12.90

42.37 ± 15.43

3 weeks

 α-MEM group (n = 3)

47.95 ± 6.29

12.20 ± 0.14

256.50 ± 31.82

34.16 ± 28.91

 UCBC group (n = 3)

43.15 ± 0.92

12.35 ± 0.21

285.50 ± 12.02

19.07 ± 1.07

 hESC group (n = 3)

45.55 ± 0.49

12.35 ± 0.35

271.50 ± 12.02

19.72 ± 1.41

 niPSC group (n = 3)

49.60 ± 8.20

12.00 ± 0.42

246.00 ± 49.50

30.98 ± 23.50

 piPSC group (n = 3)

43.95 ± 1.63

12.45 ± 0.21

283.50 ± 14.85

20.51 ± 1.66

 ciPSC group (n = 3)

47.23 ± 2.07

12.23 ± 0.29

259.67 ± 17.01

26.14 ± 6.27

4 weeks

 α-MEM group (n = 3)

44.95 ± 3.32

12.50 ± 0.28

278.50 ± 13.44

12.33 ± 0.04

 UCBC group (n = 3)

42.85 ± 0.49

12.20 ± 0.42

285.00 ± 12.73

15.94 ± 5.49

 hESC group (n = 3)

44.05 ± 0.21

12.35 ± 0.21

280.00 ± 5.66

14.27 ± 6.46

 niPSC group (n = 3)

44.55 ± 0.35

12.30 ± 0.14

276.00 ± 5.66

11.85 ± 3.85

 piPSC group (n = 3)

43.35 ± 1.34

12.30 ± 0.28

283.50 ± 16.26

16.03 ± 0.21

 ciPSC group (n = 3)

45.63 ± 1.36

12.37 ± 0.06

271.33 ± 8.50

20.44 ± 8.75

5 weeks

 α-MEM group (n = 3)

43.55 ± 4.88

12.25 ± 0.07

276.00 ± 19.80

12.13 ± 2.93

 UCBC group (n = 3)

41.45 ± 0.49

12.15 ± 0.21

293.50 ± 7.78

10.60 ± 2.10

 hESC group (n = 3)

43.00 ± 0.57

12.05 ± 0.21

280.50 ± 9.19

10.25 ± 1.62

 niPSC group (n = 3)

43.35 ± 0.64

12.50 ± 0.28

288.50 ± 2.12

29.83 ± 31.07

 piPSC group (n = 3)

42.30 ± 0.57

12.35 ± 0.21

292.50 ± 9.19

12.98 ± 4.16

 ciPSC group (n = 3)

44.57 ± 1.72

12.33 ± 0.06

277.67 ± 11.50

`13.38 ± 0.92

  1. Values represent mean ± SD. RBC red blood cell count, HB haemoglobin, HCT haematocrit, MCV mean corpuscular volume, MCH mean corpuscular haemoglobin, MCHC mean corpuscular haemoglobin concentration, RET reticulocyte count