Fig. 6

The molecular modeling of the kinase domain treated with small molecular inhibitors. A The solid ribbon modeling of the FGFR kinase domain bound to AZD4547 based on the PDB ID 4WUN: (a) represents the 2D structure of AZD4547; (b) represents the AZD4547 bound to the pocket of the FGFR intracellular kinase domain; and (c) is a 2D model of the interaction between AZD4547 and FGFR in the active molecular window. B The solid ribbon modeling of the TGFβ receptor kinase domain bound to A8301 based on the PDB ID 3TZM: (a) represents the 2D structure of A8301; (b) shows the A8301 bound to the pocket of the TGFβ receptor intracellular kinase domain; and (c) is a 2D model of the interaction between A8301 and TGFβ in the active molecular window