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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Recovery of ovarian function by human embryonic stem cell-derived mesenchymal stem cells in cisplatin-induced premature ovarian failure in mice

Fig. 6

Rescue of ovarian function by hESC-MSC transplantation after cisplatin injury. a Ovulated eggs from control, PBS, and hESC-MSC-transplanted mice at 4 weeks. b The average number of eggs ovulated per mouse. c Ovulation rate, calculated as the fraction of the number of mice in the group that ovulated. d Quality of ovulated eggs. e Embryonic development to blastocyst from ovulated eggs of treated mice following in vitro fertilization. f Percentage of fertilization with pronuclear zygotes, two cells, and blastocyst formation and hatching after in vitro fertilization. g Hatching blastocysts were immunostained for Oct3/4 (green) of the ICM, actin-phalloidin (red) in TE, and nuclear staining with DAPI (blue). h Total cell numbers in ICM and the TE and the ratio of TE cells to ICM cells. Scale bar = 100 μm (e) and 10 μm (g)

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Stem Cell Research & Therapy

ISSN: 1757-6512