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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Extracellular vesicles from adipose-derived stem cells ameliorate ultraviolet B-induced skin photoaging by attenuating reactive oxygen species production and inflammation

Fig. 5

Adipose-derived stem cell extracellular vesicles (ADSC-EVs) increased fibroblast (FB) activity and protected FBs from ultraviolet B (UVB)-induced senescence. Different doses of ADSC-EVs were separately preincubated with FBs (a) without or (b) with exposure to UVB irradiation. *P < 0.05 indicated a significant difference. (c, d) Low-dose (100 μg/mL) and high-dose (200 μg/mL) ADSC-EVs ameliorated FB senescence, evaluated by SA-β-Gal staining. Scale bars = 100 μm. *P < 0.05, UVB group compared to the control group. #P < 0.05 and $P < 0.05, UVB + 100 μg/mL group, and UVB + 200 μg/mL group compared to the UVB group, respectively. e, f The mRNA and protein expression of Col-1 and MMP-3 in four groups. *P < 0.05 indicated a significant difference

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