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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Extracellular vesicles from adipose-derived stem cells ameliorate ultraviolet B-induced skin photoaging by attenuating reactive oxygen species production and inflammation

Fig. 6

Adipose-derived stem cell extracellular vesicles (ADSC-EVs) attenuated raw 264.7 cell differentiation from M0 to M1 macrophages. a, c, and d After stimulation by lipopolysaccharide (LPS) with IFN-γ, flow cytometry shows that ADSC-EVs significantly attenuated the differentiation of raw 264.7 cells from M0 to M1 macrophages. b, e Immunofluorescent staining of iNOS and (f, g) quantitative real-time polymerase chain reaction (qPCR) quantification of TNF-α and IL-6 mRNA expression. h, i NF-κB1 signaling pathway activation by LPS with IFN-γ, suppressed by ADSC-EVs in a dose-dependent manner. Scale bars = 250 μm. *P < 0.05 indicated a significant difference; n.s., no significant difference between groups

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