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Table 1 Differential expression of genes in AC-hMSCs and nonAC-hMSCs at two different time points

From: Nonadherent culture method promotes MSC-mediated vascularization in myocardial infarction via miR-519d/VEGFA pathway

Gene name

24 h

72 h

Fold change

p value

Regulation

Fold change

p value

Regulation

C2CD4B

111.8401912

0.000145643

Up

1340.34

0.000682199

Up

SSTR2

48.09021308

0.000555557

Up

307.6615

0.000223379

Up

SLC16A6

58.22005835

0.000188778

Up

244.5447

0.000546686

Up

FAM65C

19.69493511

2.3287E-08

Up

213.9348

3.43255E-05

Up

WDR86

29.35821269

2.03996E-05

Up

190.5289

6.26129E-05

Up

GJB2

33.73311298

2.37009E-05

Up

170.4077

0.000560036

Up

CXCR4

36.63486255

0.000412617

Up

156.6291

0.000381246

Up

MMP13

18.1969967

0.001865303

Up

119.5122

1.05064E-07

Up

BMP2

20.03644612

0.000193438

Up

117.9299

2.56801E-05

Up

C2CD4A

14.64162866

0.0061597

Up

85.52482

0.000625896

Up

CLEC2B

13.20455766

0.000159395

Up

78.42479

0.002468774

Up

TNFSF10

29.04491724

0.001267072

Up

57.67481

0.000386508

Up

PRSS35

11.75846586

0.000587899

Up

56.35998

0.000564307

Up

MEGF10

21.16086411

0.002528035

Up

55.27018

5.18695E-05

Up

DUSP4

13.21396805

9.34513E-05

Up

54.87385

0.001212616

Up

TSPAN11

27.83430153

0.000297067

Up

53.68215

9.89532E-07

Up

DRAXIN

13.45155294

0.000251701

Up

51.35024

0.000127201

Up

PDK4

96.98929796

5.63176E-05

Up

46.77971

2.99919E-05

Up

ANKH

10.78789239

0.004008663

Up

46.26112

2.57026E-05

Up

RGS16

39.28019753

0.000545809

Up

45.46778

7.36326E-07

Up

RANBP3L

9.229649839

5.07326E-06

Up

38.70846

7.23795E-05

Up

ITGA2

21.59037248

5.13189E-05

Up

38.41117

0.000872801

Up

ADGRE2

9.283517607

0.008575709

Up

34.87146

6.97014E-06

Up

MMP11

16.87338081

0.00285751

Up

34.62489

0.001476287

Up

KLRK1

11.95483946

0.000405053

Up

34.56032

0.002009842

Up

BEGAIN

33.51924802

6.25637E-07

Up

30.53104

0.000704421

Up

PPL

9.869982413

0.009031407

Up

25.65778

0.000467585

Up

ABCG1

30.41288703

0.000525295

Up

24.69536

4.16571E-07

Up

CITED1

18.69977736

0.000106336

Up

24.55424

0.000276694

Up

SYTL5

36.85560246

0.000548581

Up

23.16011

0.001025661

Up

RGS17

12.57031107

0.000155551

Up

22.45184

0.000241119

Up

KIAA1211L

16.30985794

1.57458E-05

Up

22.31267

3.31962E-05

Up

GLDN

38.48393676

0.000844764

Up

21.32752

0.000790957

Up

EXPH5

15.81689248

0.001356464

Up

20.98551

0.001995397

Up

PTGDR

14.69735545

0.002868926

Up

18.19271

0.000615557

Up

CCR1

19.99097768

7.95976E-05

Up

16.40048

0.002030008

Up

RASSF10

32.93415505

0.002178622

Up

16.05662

0.000741795

Up

FAM189A1

11.84572522

0.005621653

Up

15.56768

1.4842E-06

Up

COLEC12

23.05965011

0.000724925

Up

15.25867

0.00408674

Up

KLRC1

10.05484612

0.002881202

Up

15.20619

0.000154447

Up

VEGFA

9.752636526

4.13371E-06

Up

14.73218

0.000346357

Up

XKRX

16.61076595

0.000501039

Up

14.38702

0.000172706

Up

RASGRP3

2.106425558

0.028207257

Up

13.9441

7.03918E-05

Up

ENTPD3

9.912879304

0.001624712

Up

13.76377

0.000782473

Up

YPEL4

53.61892782

3.5446E-05

Up

13.63856

0.002333755

Up

SLC7A8

11.49043722

0.011671519

Up

13.22151

0.002134691

Up

CH25H

30.44303155

0.001762942

Up

12.42755

0.004566846

Up

CYFIP2

2.709902602

0.007297695

Up

10.76685

8.22518E-05

Up

C3AR1

8.089947094

0.000411377

Up

9.559041

0.000110391

Up

F2RL1

8.771762767

0.000415707

Up

9.21932

0.000385279

Up

CPA4

0.060443451

0.004894715

Down

0.005735

3.23423E-05

Down

CNN1

0.071987351

0.002896126

Down

0.005827

0.001199281

Down

MEST

0.041677656

0.002021602

Down

0.006979

1.73885E-05

Down

KRT34

0.011913749

0.00081183

Down

0.007354

5.15434E-05

Down

DKK1

0.004639044

0.000883335

Down

0.010773

4.20121E-05

Down

LMCD1

0.029802085

2.33205E-05

Down

0.012196

0.0006374

Down

KRTAP2-3

0.011067704

0.000539452

Down

0.015092

0.000257229

Down

FAM46B

0.033933237

4.34704E-06

Down

0.0174

0.00090771

Down

MYBL1

0.029145858

1.44931E-05

Down

0.017623

0.001442927

Down

NEIL3

0.017315518

0.000108138

Down

0.01963

0.00027453

Down

KRTAP1-5

0.029877632

0.001686929

Down

0.019696

0.000129879

Down

SPC25

0.044301408

0.001309748

Down

0.027418

0.001322887

Down

THBS1

0.055229076

0.000388028

Down

0.028426

0.002471628

Down

PTX3

0.010465082

0.001271904

Down

0.028936

3.57597E-05

Down

TSPAN18

0.053314954

0.000181383

Down

0.029322

0.007596185

Down

KRTAP2-2

0.048512804

1.88464E-05

Down

0.029763

0.00057951

Down

MGAM

0.034235468

0.00061814

Down

0.030484

0.001303756

Down

ANLN

0.05142361

0.001527223

Down

0.031571

0.001433314

Down

KIRREL3

0.057630141

0.002929558

Down

0.03209

0.000359608

Down

E2F8

0.018025232

1.75885E-05

Down

0.032301

0.000149989

Down

CEP55

0.0606109

0.000871839

Down

0.033875

0.000278821

Down

CTGF

0.048584673

0.000553306

Down

0.034772

0.000177803

Down

SKA1

0.04626685

1.04503E-05

Down

0.034872

0.000282226

Down

KRTAP1-1

0.029512423

2.68546E-06

Down

0.036294

0.001195564

Down

KRTAP1-4

0.034637793

8.67165E-05

Down

0.032924

0.000393189

Down

SHCBP1

0.074874368

0.007927709

Down

0.037302

4.80244E-05

Down

CDC45

0.048785792

0.001757321

Down

0.038191

0.002567892

Down

MKI67

0.061895471

0.001531656

Down

0.039185

0.006627038

Down

ERCC6L

0.031855904

1.35451E-06

Down

0.040946

0.001070963

Down

TNFRSF11B

0.035805553

0.004205691

Down

0.041701

0.000357158

Down

ZNF367

0.048382669

0.003338013

Down

0.042294

8.8958E-05

Down

DMD

0.038750757

1.1526E-05

Down

0.042472

0.001858382

Down

CDCA8

0.038925122

0.000236484

Down

0.043372

0.000204384

Down

PADI1

0.041441366

0.000851724

Down

0.044515

7.47813E-06

Down

HIST2H3C

0.045817546

0.00054878

Down

0.045124

0.000144333

Down

TTK

0.061307423

7.72508E-05

Down

0.045391

0.000936671

Down

GABBR2

0.045546263

0.001708625

Down

0.045807

9.62305E-05

Down

FAM111B

0.027357567

4.93311E-06

Down

0.046582

0.000558007

Down

CCIN

0.051329319

0.003246805

Down

0.048819

5.93123E-05

Down

KIF15

0.066141532

0.000117669

Down

0.04886

0.001136135

Down

NCKAP5

0.066816867

0.000303257

Down

0.049423

0.001324705

Down

NTF3

0.042448723

0.001215131

Down

0.050437

0.005324032

Down

UBE2C

0.065284894

4.29692E-06

Down

0.052099

0.002768879

Down

KRT33B

0.064358986

0.00039797

Down

0.052188

0.000124335

Down

MCM10

0.046540673

0.000257847

Down

0.054035

0.003217037

Down

LMOD1

0.054276425

1.14094E-06

Down

0.055313

0.000663673

Down

LTF

0.068482765

1.6193E-05

Down

0.057596

0.000575741

Down

HIST1H3G

0.035683104

0.000992525

Down

0.058962

0.000146762

Down

CCDC85A

0.066799698

9.312090059

Down

0.059079

0.009067666

Down

NCAPG

0.073153137

6.164797229

Down

0.060212

0.037036192

Down

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Stem Cell Research & Therapy

ISSN: 1757-6512