Table 1 Summary of clinical studies

Nakamura et al., 2004 [13]

SJS × 3, chemical burns × 3

Yes

Nishida et al., 2004 [14]

SJS × 1, OCP × 3

Yes

Inatomi et al., 2006 a [15]

SJS × 7, chemical injury × 5, thermal injury × 1, pOCP × 1, idiopathic × 1

Yes

Inatomi et al., 2006 b [16]

SJS × 1, chemical injury × 1

Yes

Ang et al., 2006 [17]

SJS × 7, thermal injury × 1, chemical injury × 1, OCP × 1

Yes

Nakamura et al., 2007 [18]

SJS × 3, chemical injury × 3

NA

Satake et al., 2008 [19]

SJS × 2, pOCP × 2

NA

Chen et al., 2009 [20]

Chemical burn × 3, thermal burn × 1

NA

Ma et al., 2009 [21]

Chemical burn × 3, thermal burn × 2

NA

Priya et al., 2011 [22]

SJS × 1, chemical injury × 9

Yes

Satake et al., 2011 [23]

SJS × 12, chemical or thermal injury × 11, OCP × 9, pOCP × 7, gelatinous drop-like dystrophy × 1

Yes

Nakamura et al., 2011 [24]

SJS × 11, chemical or thermal injury × 1, OCP × 4, squamous cell carcinoma × 2, graft-versus-host disease × 1

Yes

Takeda et al., 2011 [25]

Chemical burn × 1, thermal burn × 2

NA

Burillon et al., 2012 [26]

Corneal burn × 9, neuroparalytic keratitis × 2, rosacea keratitis × 3, Lyell syndrome × 4, severe trachoma × 1, contact lens hypoxia × 1, congenital aniridia × 1, cystinosis × 1, severe Groenouw dystrophy × 1, hepatitis C × 1, contact lens hypoxia + congenital aniridia × 2

Unclear^a

Hirayama et al., 2012 [27]

Chemical injury × 12, pOCP × 12 (trachoma × 4, Behcet’s disease × 2, thermal burn × 1 and post keratitis × 5), SJS × 4, OCP × 4

Partially (27/32)

Chen et al., 2012 [28]

Chemical burn × 4, thermal burn × 2

NA

Sotozono et al., 2013 [29]

SJS × 21, OCP × 10, chemical or thermal injury × 7, idiopathic × 3, radiation keratopathy × 1, graft-versus-host disease × 1, congenital aniridia × 1, Salzmann’s corneal degeneration × 1, drug toxicity × 1

Unclear^a

Sotozono et al., 2014 [30]

SJS × 3, thermal injury × 3, chemical injury × 2, OCP × 2

Unclear^a

Kolli et al., 2014 [31]

Chemical burn × 2

Partially (1/2)

Dobrowolski et al., 2015 [32]

Aniridia × 17

NA

Prabhasawat et al., 2016 [33]

SJS × 10, chemical burn × 7, multiple eye surgery × 1, advanced pterygium × 1, ocular trauma × 1

Yes

Baradaren-Rafii et al., 2017 [34]

Chemical burn × 14

Yes

Kim et al., 2018 [35]

SJS × 6, OCP × 1, chemical burn × 1

NA

Wang et al., 2019 [36]

Chemical injury × 16, thermal injury × 18

NA