Table 1 The experimental groups of young and old rats
Group | Treatment | Endpoint* |
|---|---|---|
Young control | Control | 7 days and 14 days |
Old control | Control | 7 days and 14 days |
Young UUO | UUO | 7 days and 14 days after UUO |
Old UUO | UUO | 7 days and 14 days after UUO |
Young-UUO + Y-MSC-EV | Y-MSC-EVs injection with tail vein at day 0 after UUO | 7 days and 14 days after UUO |
Young-UUO + O-MSC-EV | Y-MSC-EVs injection with tail vein at day 0 after UUO | 7 days and 14 days after UUO |
Young-UUO + LV-rno-miR-294 inhibitor | LV-rno-miR-294inhibitor injection with tail vein 3 days before UUO | 7 days and 14 days after UUO |
Young-UUO + LV-rno-miR-133 inhibitor | LV-rno-miR-133inhibitor injection with tail vein 3 days before UUO | 7 days and 14 days after UUO |
Old-UUO + LV-rno-miR-294 mimic | LV-rno-miR-294 mimic injection with tail vein 3 days before UUO | 7 days and 14 days after UUO |
Old-UUO + LV-rno-miR-133 mimic | LV-rno-miR-133 mimic injection with tail vein 3 days before UUO | 7 days and 14 days after UUO |
Young-UUO + LV-NC | LV-NC injection with tail vein 3 days before UUO | 7 days and 14 days after UUO |
Old-UUO + LV-NC | LV-NC injection with tail vein 3 days before UUO | 7 days and 14 days after UUO |