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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Enrichment differentiation of human induced pluripotent stem cells into sinoatrial node-like cells by combined modulation of BMP, FGF, and RA signaling pathways

Fig. 7

Graphic abstract. Working model of enriched differentiation of SANLC from hiPSC by the BMP4 + PD + BMS (BPM) treatment versus the GiWi method alone. Simultaneous activation of BMP and inhibition of RA and FGF signaling pathways during cardiac mesoderm stage of the GiWi-induced hiPSC differentiation strongly favor a SAN-specific gene transcriptional landscape leading to enhanced pacemaker cell specification

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Stem Cell Research & Therapy

ISSN: 1757-6512