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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Placenta-derived multipotent mesenchymal stromal cells: a promising potential cell-based therapy for canine inflammatory brain disease

Fig. 5

Bioactive factors associated with canine ASC and PMSC mediated immunosuppression differs. Canine adipose-derived MSCs (ASCs) and placenta-derived MSCs (PMSCs) increase production of vascular endothelial growth factor (VEGF) and IL-6. a Both canine ASCs and PMSCs mildly increased production of VEGF when co-cultured with mitogen (ConA) activated peripheral blood mononuclear cells (PBMCs). b Canine ASCs and PMSCs upregulated IL-6 production; however, PMSCs secreted higher levels of IL-6 as compared to ASCs. c Production of IL-8 by canine ASCs was comparable to basal levels of IL-8 produced by stimulated PBMCs; however, PMSCs increased levels of IL-8 greater than basal levels. Additionally, regulation of inflammatory mediators by canine ASCs and PMSCs was similar. d IL-2 production from stimulated PBMCs was mildly reduced by both canine ASCs and PMSCs. e Canine ASCs and PMSCs inhibit production of tumor necrosis factor alpha (TNFα) by stimulated PBMCs to comparable levels. Data presented as mean and standard error. ConA, concanavalin A IL, interleukin; TNFα, tumor necrosis factor alpha; VEGF, vascular endothelial growth factor

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