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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: BMMSC-sEV-derived miR-328a-3p promotes ECM remodeling of damaged urethral sphincters via the Sirt7/TGFβ signaling pathway

Fig. 2

Therapeutic effects of BMMSC-sEV in fibroblasts. a–c The expression levels of elastin and collagen I in primary human fibroblasts treated with different concentrations of BMMSC-derived sEV. d–j The expression levels of elastin, collagen I, Smad7, TGF-β1, Smad2/3, and p-Smad2/3 in fibroblasts that were treated with PBS, NRK-52E-sEV (10 μg/ml), or BMMSC-sEV (10 μg/ml) for 48 h. k The phosphorylation level of Smad2/3. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001

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Stem Cell Research & Therapy

ISSN: 1757-6512