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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: BMMSC-sEV-derived miR-328a-3p promotes ECM remodeling of damaged urethral sphincters via the Sirt7/TGFβ signaling pathway

Fig. 4

BMMSC-sEV promote urethral ECM remodeling in SUI rats via the TGF-β1 signaling pathway. a Western blot analysis showed the expression levels of elastin, collagen I, collagen III, TGF-β1, Smad2/3, and p-Smad2/3 in normal rats and SUI rats treated with PBS, NRK-52E-sEV, BMMSC, and BMMSC-sEV. bg Normalized data shown in a. h Quantified data of the phosphorylation level of Smad2/3. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001

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