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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Prophylactic therapy with human amniotic fluid stem cells improved survival in a rat model of lipopolysaccharide-induced neonatal sepsis through immunomodulation via aggregates with peritoneal macrophages

Fig. 3

Distribution of hAFSCs after intraperitoneal transplantation. Distribution of hAFSCs after intraperitoneal injection. The distribution of hAFSCs (n = 3) after injection was detected by in vivo imaging (IVIS®). Cells were labeled with DiR and injected 3 h before hAFSCs injection. a The representative pictures from the ventral side. b Pictures and graphs of each organ in the time-course of distribution in LPS and hAFSCs+LPS groups. c In vivo image in the peritoneal cavity 48 h after LPS administration. DiR-labeled hAFSCs were aggregated as white dashed lines outlines (scale bars, 10 mm). d Microscopic analysis of a single aggregate showed that the cellular aggregates were mainly composed of human mitochondria-positive hAFSCs surrounded by CD68+ peritoneal macrophages (scale bars, 100 μm)

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Stem Cell Research & Therapy

ISSN: 1757-6512