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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: METTL1-mediated m7G methylation maintains pluripotency in human stem cells and limits mesoderm differentiation and vascular development

Fig. 6

METTL1 silencing promotes angiogenesis and increased CD31 and SM22α expression in teratomas. a Representative images from control and METTL1-KD2 teratomas stained for CD31 (red), and SM22α (green); nuclei were counterstained with DAPI (blue). The number of cavities per hpf and relative tube area were determined using ImageJ software. Scale bar, 50 μm. b Representative images of vessels at high magnification (× 100) and quantification of CD31 and SM22α intensities in control and METTL1-KD teratomas; nuclei were counterstained with DAPI. Scale bar, 10 μm. Data are presented as mean ± SEM; n = 3; **P < 0.01, ***P < 0.001

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