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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Osteocyte-derived exosomes induced by mechanical strain promote human periodontal ligament stem cell proliferation and osteogenic differentiation via the miR-181b-5p/PTEN/AKT signaling pathway

Fig. 6

Exosomal miR-181b-5p regulates HPDLSC proliferation through the PTEN/AKT signaling pathway. a–d The expression levels of genes in the PTEN/AKT signaling pathway including CCND1, PIK3CA, PIK3R1, and PTEN after inhibition or overexpression of miR-181b-5p were verified using real-time PCR. e Western blotting assay was performed to evaluate the expression of PTEN and p-AKT. f, g Quantitative analysis of western blotting assay using ImageJ. h Western blotting assay showed the effect of PTEN inhibitor and miR-181b-5p on the expression of pAKT. i Quantitative analysis of western blotting assay using ImageJ (*P < 0.05, **P < 0.01, and ***P < 0.001)

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