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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Formation and optimization of three-dimensional organoids generated from urine-derived stem cells for renal function in vitro

Fig. 5

Expression of renal-specific markers in USCs and 3D organoids via RT-qPCR. a The expression level of specific proximal tubule AQP1. There was near none AQP1 expression in USCs, but three groups of organoids all had AQP1 expression. The AQP1 expression level of USC-organoids with kECM was between USC-organoids and renal organoids. b The expression level of kidney endocrine product EPO. Only USC-organoids with kECM and renal organoids had clear EPO expression. c The expression level of kidney glomerular marker Podocin. The Podocin expression level of USC-organoids with kECM was between USC-organoids and renal organoids. d The expression level of kidney glomerular marker Synaptopodin. The Synaptopodin expression level of USC-organoids with kECM was between USC-organoids and renal organoids. The AQP1, EPO, Podocin, and Synaptopodin expression level of USCs, USC-organoids, and USC-organoids with kECM were all significantly lower than renal organoids (three replicated samples for each group, data presented as mean ± SD)

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Stem Cell Research & Therapy

ISSN: 1757-6512