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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Exosomes derived from atorvastatin-pretreated MSC accelerate diabetic wound repair by enhancing angiogenesis via AKT/eNOS pathway

Fig. 6

Proangiogenic capacity of ATV-Exos in HUVECs was attenuated when AKT/eNOS pathway was blocked. a The phosphorylation level of AKT and eNOS as well as the relative protein expression level of PTEN of HUVEC treated with HG medium supplemented with Exos, ATV-Exos, and ATV-Exos+LY 294002 by Western blotting. b Cell proliferation of HUVEC for 1, 3, and 7 days. c The images of cell migration and tube formation of HUVEC with different treatments. d Quantitative analysis of cell migration ability. e Quantitative analysis of tube formation ability. f The VEGF concentration of supernatant in HG medium supplemented with Exos, ATV-Exos, and ATV-Exos+LY 294002 through Elisa. g The relative expression level of ANG1, PDGF, bFGF, and EGF of HUVEC examined by qRT-PCR. LY: LY 294002. *P < 0.05

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