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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Transcriptional profiling reveals altered biological characteristics of chorionic stem cells from women with gestational diabetes

Fig. 3

Positively and negatively regulated pathway analysis and regulatory network visualisation. a, b IPA canonical pathway analysis of positively and negatively regulated pathways in GDM-CMSCs. The x-axis indicates the altered canonical pathways in GDM-CMSCs. The left y-axis indicates the statistical significance p value, calculated using Fisher’s exact test. The right y-axis represents the ratio of the number of dataset genes that map to all known pathway genes. c, d Positively regulated canonical pathways and associated genes. Hierarchical clustering maps indicate the expression of genes involved in BMP, Wnt/β-catenin, FGF signalling, and Rho family signalling. From left to right on the clustering maps are presenting as GDM6, GDM7, and GDM8 samples. Each gene is normalised to a mean expression of 3 Healthy-CMSCs samples. Blue and red indicate below and above mean expression, respectively, with values indicating log2 fold change. e, f Negatively regulated canonical pathways and associated genes. Interaction networks were generated by Cytoscape visualisation based on DEGs. Hierarchical clustering map showed a significant reduction in ALDH family gene expression in GDM-CMSCs and regulators of the Nrf2 pathway

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