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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Hepatocyte growth factor (HGF) and stem cell factor (SCF) maintained the stemness of human bone marrow mesenchymal stem cells (hBMSCs) during long-term expansion by preserving mitochondrial function via the PI3K/AKT, ERK1/2, and STAT3 signaling pathways

Fig. 2

hBMSCs cultured in SHED-CM had less senescence and maintained stemness during long-term expansion. a Representative images of β-gal stained passage 3 (P3) and passage 8 (P8) hBMSCs cultured in DMEM, SHED-CM (P8-SHED-CM), and hBMSCs-CM (P8-hBMSCs-CM), and corresponding rate (%) of β-gal-positive cells per group. b Relative mRNA expression levels of senescence (p16 and p21) and stemness (Nanog and OCT4) markers per group. *P < 0.05, **P < 0.01, ***P < 0.001

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Stem Cell Research & Therapy

ISSN: 1757-6512