Table 4 Therapeutic uses of ATE

[24]

Yunfan He

Adipogenesis and angiogenesis induction of ALE

C57BL/6 mice wound model

1. ALE enhanced wound healing in mice

2. ALE induced angiogenesis and adipogenesis in vitro and in vivo

[28]

Jenny F. Lo’pez

ASC, fibroblasts, endothelial cells, and keratinocytes were cultured with ATE

1. ATE contains higher concentrations of KGF and promotes keratinocyte proliferation

2. ATE stimulates fibroblast and adipose stem cell migration

[63]

You Kyung Na

HDF was incubated with ATSC-Ex

Mice circular cutaneous wound model

1. Topical application of ATSC-Ex accelerates wound healing in vivo

2. ATE promotes HDF proliferation and migration and ECM protein production

[64]

Mingwu Deng

Dermal fibroblasts were cultured with different concentrations of FE and then were exposed to UVB light

Female BALB/c nude mice skin photoaging model

1. FE increases cell proliferation and abrogates UVB irradiation-induced cell cycle arrest.

2. FE prevents UVB-Induced cell aging and intracellular ROS, promoted the expression of GPX-1 and COL-1 in vitro.

3. Antiaging effects of FE on the skin of UVB-irradiated nude mice

[26]

Yuda Xu

Fibroblasts were treated with Ceffe

Female BALB/c nude mice skin photoaging model

1. Ceffe increased the proliferation of human skin fibroblasts

2. Ceffe enhances ECM production and inhibits collagen degradation

[23]

Ziyou Yu

The HUVECs were treated with different concentrations of FE

Nude mice hindlimb ischemia model

1. FE attenuated tissue necrosis in a hindlimb ischemia mouse model and enhanced HUVEC proliferation and migration in a dose-dependent manner

2. FE improved HUVEC tube formation in vitro and promoted vascular formation in vivo as detected using the Matrigel assay

[27]

Yizuo Cai

HUVECs were treated with increasing concentrations of FE

Rat skin flap model

1. Fat extract contains multiple growth factors and increases the proliferation, migration, and tube formation of human umbilical vein endothelial cells 2.FE improves skin flap survival in rats and skin flap angiogenesis

[65]

Daejong Jeon

Male C57BL/6J mice epilepsy model

1. ASCs-E does not affect the seizure threshold and severity

2. ASCs-E have an antiepileptogenic effect in the pilocarpine-induced epilepsy model

3. ATE can reduce the number of spontaneous recurrent epilepsy (SRS) and reduce epilepsy behavior in pilocarpine-induced mouse epilepsy