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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Extracellular vesicles from human mesenchymal stem cells expedite chondrogenesis in 3D human degenerative disc cell cultures

Fig. 3

Chondrocyte-like cell characteristics of DCs isolated from degenerated IVDs after hMSCs’ sEV treatment. a The bar graph presents the percentage of KRT19-positive cells in histological sections of DCs treated with sEVs compared to control from day 7 to 28. b Representative images showing the expressions of KRT19 in DC pellets treated with sEVs from day 7 to 28. c The bar graph illustrates the quantitative level of SOX9-positive cells in histological sections of DC pellets for the same time points. d Representative images showing the expression of SOX9 in DC pellets treated with sEVs from day 7 to 28. Quantitative results in a and c are presented as pixels/square micrometer while green colors in b and d indicated by red arrows are the positive expressions of KRT19, while yellow colors are that of SOX9 in the pellets, respectively. Blue dots are the nuclei of DCs. Data represents mean ± SEM (n = 5). *p < 0.05

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Stem Cell Research & Therapy

ISSN: 1757-6512