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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Extracellular vesicles from human mesenchymal stem cells expedite chondrogenesis in 3D human degenerative disc cell cultures

Fig. 5

Expressions of collagen type II (COLIIA1) and aggrecan (ACAN) in DC pellets over a 28-day period. a The bar graphs illustrate the level of COLIIA1-positive cells in DC pellets. b Representative images showing the expressions of COLIIA1 in DC pellets treated with sEVs from day 7 to 28. c The bar graphs illustrate the level of ACAN-positive cells in DC pellets. d Representative images showing the expressions of ACAN in DC pellets treated with sEVs from day 7 to 28. Quantitative results in a and c are presented as pixels/square micrometer while yellow colors indicated by red arrows in b and d are positive expressions of the proteins in the pellets. Blue dots are the nuclei of DCs. Data represents mean ± SEM (n = 5). *p < 0.05 and **p < 0.01

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Stem Cell Research & Therapy

ISSN: 1757-6512