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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: miR-137 boosts the neuroprotective effect of endothelial progenitor cell-derived exosomes in oxyhemoglobin-treated SH-SY5Y cells partially via COX2/PGE2 pathway

Fig. 2

Characterization of EPC-EXs and transfection of EPC-EXs into SH-SY5Y cells. a Representative results from the nanoparticle analysis of EPC-EXs. b The size of EPC-EXs, EPC-EXsSC, and EPC-EXsmiR-137 were comparable, n = 6. c There were no differences on the concentration of EPC-EXs, EPC-EXsSC, and EPC-EXsmiR-137, n = 6. d Representative micrographs of PKH26-labeled EPC-EXs in SH-SY5Y cells of different groups. e The amount of EPC-EXs, EPC-EXsSC, and EPC-EXsmiR-137 took up by the neurons was comparable, n = 6. f Representative micrographs of PKH26-labeled EPC-EXs in SH-SY5Y cells after the administration of inhibitors involved in the major EXs uptake pathways. g Pitstop 2, Gebistein, and Ly294002 decreased the fluorescence intensity of EPC-EXs in SH-SY5Y cells, n = 6. *P < 0.05 and **P < 0.01 vs. control group

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Stem Cell Research & Therapy

ISSN: 1757-6512