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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Mesenchymal stem cells inhibited the differentiation of MDSCs via COX2/PGE2 in experimental sialadenitis

Fig. 6

Scheme of MSCs inhibited the differentiation of MDSCs in SS. MDSCs and PMN-MDSCs increased and M-MDSCs decreased significantly in NOD mice with sialadenitis. MSCs ameliorated SS-like syndrome by suppressing the differentiation of MDSCs, PMN-MDSCs, and M-MDSCs via COX2/PGE2 and IFN-β. MSCs rectified the imbalance of PMN-MDSCs and M-MDSCs. And MSCs promoted the suppressive ability by improving the immature or undifferentiated phenotype and increased the Arg-1, gp91phox, and iNOS expression in MDSCs of NOD mice

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Stem Cell Research & Therapy

ISSN: 1757-6512