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Table 1 Characteristics of the included studies

From: Efficacy of stem cell therapy for burn wounds: a systematic review and meta-analysis of preclinical studies

Study (year) Country Animal (number) Burn area (cm2) Burn degree Cell type Origin Transplant type Cell number Method Placebo Outcome index
Abbas et al., 2018 [50] Turkey Wistar rats (40) 10.45 Third MSCs Bone marrow Allogenic 1 × 106 Subcutaneous injection PBS (1) Blood vessel density, (2) IL-1, (3) VEGF, (4) TNF-α
Amini-Nik et al., 2018 [17] Canada Nude mice (10) 25 Third MSCs Burned tissue Autologous 5 × 106 Subcutaneous injection No (1) Wound healing rate
de Andrade et al., 2020 [41] Brazil Wistar rats (48) 20 Third ASCs Adipose Xenogenic 1.5 × 106 Subcutaneous injection PBS (1) Wound healing rate, (2) collagen I and III, (3) VEGF
Aryan et al., 2018 [45] Iran Wistar rats (32) 9 Second MSCs Bone marrow Xenogenic NA NA No (1) Blood vessel density
Babakhani et al., 2020 [42] Iran Wistar rats (30) 2.25 Second HFSCs Hair follicle Allogenic 1 × 106 Subcutaneous injection PBS (1) Wound healing rate, (2) total collagen
Bliley et al., 2016 [38] USA Nude mice (24) 0.79 Third ASCs Adipose Xenogenic 6.8 × 106 Subcutaneous injection PBS (1) Blood vessel density, (2) collagen I and III
Caliari-Oliveira et al., 2016 [28] Brazil Wistar rats (28) 45 Third MSCs Bone marrow Xenogeneic 5 × 106 Subcutaneous injection PBS (1) Wound healing rate, (2) blood vessel density, (3) total collagen
Chang et al. #1, 2018 [39] China Wistar rats (6) 0.5 Third ASCs Adipose Autologous 5 × 106 Subcutaneous injection Medium (1) Wound healing rate
Chang et al. #2, 2018 [39] China Wistar rats (6) 0.5 Third ASCs Adipose Allogenic 5 × 106 Subcutaneous injection Medium (1) Wound healing rate
Feng et al., 2019 [37] China SD rats (18) 1 Third ASCs Adipose Allogenic 5 × 105 Subcutaneous injection PBS (1) Blood vessel density
Foubert et al. #1, 2016 [36] USA Gottingen minipigs (10) 10 Third SVF Adipose Autologous 2.5 × 106 Subcutaneous injection LR (1) Wound healing rate, (2) blood vessel density
Foubert et al. #2, 2016 [36] USA Gottingen minipigs (10) 10 Third SVF Adipose Autologous 2.5 × 106 Spray LR (1) Wound healing rate, (2) blood vessel density
Foubert et al. #1, 2017 [52] USA Gottingen minipigs (8) 10 Third SVF Adipose Autologous 19.5 × 106 Subcutaneous injection LR (1) Blood vessel density
Foubert et al. #2, 2017 [52] USA Gottingen minipigs (10) 10 Third SVF Adipose Autologous 21 × 106 Intravenous injection LR (1) Blood vessel density
Franck et al., 2019 [16] Brazil Wistar rats (23) 4.84 Third ASCs Adipose Allogenic 3.2 × 106 Subcutaneous injection No (1) Total collagen, (2) collagen I and III
Imam et al., 2019 [44] Egypt Albino rats (20) 2 Third MSCs Bone marrow Allogenic 1 × 106 Subcutaneous injection No (1) IL-1, (2) VEGF
Li et al., 2019 [29] China Wistar rats (18) NA Third MSCs Bone marrow Allogenic 1 × 106 Subcutaneous injection PBS (1) IL-1, (2) VEGF, (3) TNF-α
Liu et al., 2014 [47] China Wistar rats (28) NA Third MSCs Umbilical cord Xenogenic 5 × 106 Subcutaneous injection PBS (1) Wound healing rate, (2) blood vessel density, (3) IL-1, (4) VEGF, (5) TNF-α
Mahmood et al., 2019 [46] Pakistan SD rats (12) 4 Third MSCs Umbilical cord Xenogeneic NA Subcutaneous injection No (1) Wound healing rate, (2) VEGF
Xue et al., 2013 [43] China Mice (20) NA NA MSCs Bone marrow Xenogenic 1 × 106 Subcutaneous injection PBS (1) Wound healing rate, (2) blood vessel density
Yang et al., 2019—1 [51] China BALB/c mice (30) 1 NA ESCs Epidermis Allogenic 3.2 × 106 Subcutaneous injection No (1) Wound healing rate, (2) blood vessel density,
Yang et al., 2019—2 [40] China BALB/c mice (30) 1 NA ESCs Epidermis Allogenic 3.2 × 106 Subcutaneous injection No (1) Wound healing rate, (2) blood vessel density
Zhang et al., 2015 [48] China SD rats (84) 1.77 NA MSCs Umbilical cord Xenogeneic 2 × 106 Subcutaneous injection No (1) Wound healing rate, (2) TNF-α
Zhou et al., 2019—1 [30] China C57BL/6 mice (36) 2.25 Third MSCs Umbilical cord Xenogenic NA NA Medium (1) Wound healing rate, (2) blood vessel density
Zhou et al., 2019—2 [49] China SD rats (18) 2 Third ASCs Adipose Autologous 6 × 106 Subcutaneous injection PBS (1) Blood vessel density
  1. ASCs adipose-derived stem cells, ESCs epidermal stem cells, HFSCs hair follicle stem cells, IL-1 Interleukin-1, LR lactate ringer, MSCs mesenchymal stem cells, NA not available, PBS phosphate-buffered saline, SD Sprague Dawley, SVF stromal vascular fraction, TNF-α tumor necrosis factor-α, VEGF vascular endothelial growth factor