Table 1 Characteristics of the included studies
Study (year) | Country | Animal (number) | Burn area (cm2) | Burn degree | Cell type | Origin | Transplant type | Cell number | Method | Placebo | Outcome index |
|---|---|---|---|---|---|---|---|---|---|---|---|
Abbas et al., 2018 [50] | Turkey | Wistar rats (40) | 10.45 | Third | MSCs | Bone marrow | Allogenic | 1 × 106 | Subcutaneous injection | PBS | (1) Blood vessel density, (2) IL-1, (3) VEGF, (4) TNF-α |
Amini-Nik et al., 2018 [17] | Canada | Nude mice (10) | 25 | Third | MSCs | Burned tissue | Autologous | 5 × 106 | Subcutaneous injection | No | (1) Wound healing rate |
de Andrade et al., 2020 [41] | Brazil | Wistar rats (48) | 20 | Third | ASCs | Adipose | Xenogenic | 1.5 × 106 | Subcutaneous injection | PBS | (1) Wound healing rate, (2) collagen I and III, (3) VEGF |
Aryan et al., 2018 [45] | Iran | Wistar rats (32) | 9 | Second | MSCs | Bone marrow | Xenogenic | NA | NA | No | (1) Blood vessel density |
Babakhani et al., 2020 [42] | Iran | Wistar rats (30) | 2.25 | Second | HFSCs | Hair follicle | Allogenic | 1 × 106 | Subcutaneous injection | PBS | (1) Wound healing rate, (2) total collagen |
Bliley et al., 2016 [38] | USA | Nude mice (24) | 0.79 | Third | ASCs | Adipose | Xenogenic | 6.8 × 106 | Subcutaneous injection | PBS | (1) Blood vessel density, (2) collagen I and III |
Caliari-Oliveira et al., 2016 [28] | Brazil | Wistar rats (28) | 45 | Third | MSCs | Bone marrow | Xenogeneic | 5 × 106 | Subcutaneous injection | PBS | (1) Wound healing rate, (2) blood vessel density, (3) total collagen |
Chang et al. #1, 2018 [39] | China | Wistar rats (6) | 0.5 | Third | ASCs | Adipose | Autologous | 5 × 106 | Subcutaneous injection | Medium | (1) Wound healing rate |
Chang et al. #2, 2018 [39] | China | Wistar rats (6) | 0.5 | Third | ASCs | Adipose | Allogenic | 5 × 106 | Subcutaneous injection | Medium | (1) Wound healing rate |
Feng et al., 2019 [37] | China | SD rats (18) | 1 | Third | ASCs | Adipose | Allogenic | 5 × 105 | Subcutaneous injection | PBS | (1) Blood vessel density |
Foubert et al. #1, 2016 [36] | USA | Gottingen minipigs (10) | 10 | Third | SVF | Adipose | Autologous | 2.5 × 106 | Subcutaneous injection | LR | (1) Wound healing rate, (2) blood vessel density |
Foubert et al. #2, 2016 [36] | USA | Gottingen minipigs (10) | 10 | Third | SVF | Adipose | Autologous | 2.5 × 106 | Spray | LR | (1) Wound healing rate, (2) blood vessel density |
Foubert et al. #1, 2017 [52] | USA | Gottingen minipigs (8) | 10 | Third | SVF | Adipose | Autologous | 19.5 × 106 | Subcutaneous injection | LR | (1) Blood vessel density |
Foubert et al. #2, 2017 [52] | USA | Gottingen minipigs (10) | 10 | Third | SVF | Adipose | Autologous | 21 × 106 | Intravenous injection | LR | (1) Blood vessel density |
Franck et al., 2019 [16] | Brazil | Wistar rats (23) | 4.84 | Third | ASCs | Adipose | Allogenic | 3.2 × 106 | Subcutaneous injection | No | (1) Total collagen, (2) collagen I and III |
Imam et al., 2019 [44] | Egypt | Albino rats (20) | 2 | Third | MSCs | Bone marrow | Allogenic | 1 × 106 | Subcutaneous injection | No | (1) IL-1, (2) VEGF |
Li et al., 2019 [29] | China | Wistar rats (18) | NA | Third | MSCs | Bone marrow | Allogenic | 1 × 106 | Subcutaneous injection | PBS | (1) IL-1, (2) VEGF, (3) TNF-α |
Liu et al., 2014 [47] | China | Wistar rats (28) | NA | Third | MSCs | Umbilical cord | Xenogenic | 5 × 106 | Subcutaneous injection | PBS | (1) Wound healing rate, (2) blood vessel density, (3) IL-1, (4) VEGF, (5) TNF-α |
Mahmood et al., 2019 [46] | Pakistan | SD rats (12) | 4 | Third | MSCs | Umbilical cord | Xenogeneic | NA | Subcutaneous injection | No | (1) Wound healing rate, (2) VEGF |
Xue et al., 2013 [43] | China | Mice (20) | NA | NA | MSCs | Bone marrow | Xenogenic | 1 × 106 | Subcutaneous injection | PBS | (1) Wound healing rate, (2) blood vessel density |
Yang et al., 2019—1 [51] | China | BALB/c mice (30) | 1 | NA | ESCs | Epidermis | Allogenic | 3.2 × 106 | Subcutaneous injection | No | (1) Wound healing rate, (2) blood vessel density, |
Yang et al., 2019—2 [40] | China | BALB/c mice (30) | 1 | NA | ESCs | Epidermis | Allogenic | 3.2 × 106 | Subcutaneous injection | No | (1) Wound healing rate, (2) blood vessel density |
Zhang et al., 2015 [48] | China | SD rats (84) | 1.77 | NA | MSCs | Umbilical cord | Xenogeneic | 2 × 106 | Subcutaneous injection | No | (1) Wound healing rate, (2) TNF-α |
Zhou et al., 2019—1 [30] | China | C57BL/6 mice (36) | 2.25 | Third | MSCs | Umbilical cord | Xenogenic | NA | NA | Medium | (1) Wound healing rate, (2) blood vessel density |
Zhou et al., 2019—2 [49] | China | SD rats (18) | 2 | Third | ASCs | Adipose | Autologous | 6 × 106 | Subcutaneous injection | PBS | (1) Blood vessel density |